Ketamine does not increase intracranial pressure compared with opioids: meta-analysis of randomized controlled trials
J Anesth. 2014 May 24. [Epub ahead of print]
Ketamine is traditionally avoided in sedation management of patients with risk of intracranial hypertension. However, results from many clinical trials contradict this concern. We critically analyzed the published data of the effects of ketamine on intracranial pressure (ICP) and other cerebral hemodynamics to determine whether ketamine was safe for patients with hemodynamic instability and brain injuries.Methods:
Critical Care Medicine: July 2013 - Volume 41 - Issue 7 - p 1782-1789
Westfall, Mark DO; Krantz, Steve EMT-P; Mullin, Christopher MS; Kaufman, Christopher PhD
Objective: The objective of this study was to conduct a meta-analysis of literature examining rates of return of spontaneous circulation from load-distributing band and piston-driven chest compression devices as compared with manual cardiopulmonary resuscitation.
Renaissance of base deficit for the initial assessment of trauma patients: a base deficit- based classification for hypovolemic shock developed on data from 16,305 patients derived from the TraumaRegister DGU®
Critical Care 2013, 17:R42
Manuel Mutschler1,2*, Ulrike Nienaber3, Thomas Brockamp1, Arasch Wafaisade1, Tobias Fabian1, Thomas Paffrath1, Bertil Bouillon1, Marc Maegele1 and the TraumaRegister DGU4
Introduction: The recognition and management of hypovolemic shock still remain an important task during initial trauma assessment. Recently, we have questioned the validity of the Advanced Trauma Life Support (ATLS) classification of hypovolemic shock by demonstrating that the suggested combination of heart rate, systolic blood pressure and Glasgow Coma Scale displays substantial deficits in reflecting clinical reality. The aim of this study was to introduce and validate a new classification of hypovolemic shock based upon base deficit (BD) at emergency department (ED) arrival.